Lamming lab
Lamming Laboratory
University of Wisconsin-Madison School of Medicine and Public Health
Division of Endocrinology, Diabetes and Metabolism
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The Lamming laboratory's goal is to understand how nutrient-responsive signaling pathways can be harnessed to promote health and longevity. We are primarily focused on the physiological role played by the mechanistic target of rapamycin (mTOR), a protein kinase that through a diverse set of substrates regulates complex cellular processes, including growth, metabolism, and aging. Recent work has shown that rapamycin, an inhibitor of mTOR signaling, can improve both health and longevity in model organisms including mammals. Understanding and manipulating the mTOR signaling pathway through dietary, pharmaceutical or genetic interventions in mouse models may provide insight into the treatment of age-related diseases, including diabetes, Alzheimer's disease, cancer, and Hutchinson-Gilford Progeria Syndrome.

The Biology of Aging and mTOR

Dietary Interventions in Age-Related Disease


Recent publications: Recent reviews: Recent publications: Recent reviews: Recent publications: Recent reviews:
Older selected publications:

Lamming DW, Demirkan G, Boylan JM, Mihaylova MM, Peng T, Ferreira J, Neretti N, Salomon A, Sabatini DM, Gruppuso PA. Hepatic signaling by the mechanistic target of rapamycin complex 2 (mTORC2). FASEB J. 2014; 28(1):300-15. doi: 10.1096/fj.13-237743.(PubMed Link) (PDF)

Lamming DW, Ye L, Astle CM, Baur JA, Sabatini DM, Harrison DE. Young and old genetically heterogeneous HET3 mice on a rapamycin diet are glucose intolerant but insulin sensitive. Aging Cell. 2013; 12(4):712-8. doi: 10.1111/acel.12097.(PubMed Link) (PDF)

Lamming DW, Ye L, Katajisto P, Goncalves MD, Saitoh M, Stevens DM, Davis JG, Salmon AB, Richardson A, Ahima RS, Guertin DA, Sabatini DM, Baur JA. Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity. Science. 2012; 335(6076):1638-43. Epub 2012/03/31. doi: 10.1126/science.1215135.(PubMed Link) (PDF)

Dudley Lamming, Ph.D.
Full Publication list
BS, Massachusetts Institute of Technology
PhD, Harvard University
Postdoc, Whitehead Institute for Biomedical Research

Joined the UW-Madison Faculty in 2014.

Dr. Lamming is an Assistant Professor in the Division of Endocrinology, Diabetes and Metabolism at the UW-Madison School of Medicine and Public Health. Postdoctoral, Ph.D. students, M.D. students and undergraduates interested in pursuing research in the Lamming lab should contact Dr. Lamming directly at

Dr. Lamming is a member of the following centers and graduate training programs:

The Lamming lab is supported in part by the NIH National Institute on Aging, the American Federation For Aging Research, the Glenn Foundation for Medical Research, the Progeria Research Foundation, and the Wisconsin Partnership Program.

Lab Members:
Sebastian Arriola, Ph.D.
American Diabetes Association Postdoctoral Fellow
  • BS, University of the Republic, Montevideo Uruguay
  • PhD, Virginia Tech
Nicole Cummings
Biology of Aging T32 Training Grant Predoctoral trainee
Graduate Student, Endocrinology and Reproductive Physiology
  • BS, Colorado State University
Heidi Pak
Graduate Student, Nutritional Sciences
  • BS, University of Nevado, Reno
Deyang (Charles) Yu
American Heart Association Predoctoral Fellow
Graduate Student, Molecular and Environmental Toxicology
  • Bachelor of Medicine, Wuhan University, China
Jacqueline Brinkman
Research Intern
  • BS, University of Illinois at Urbana-Champaign
Jay Tomasiewicz
Research Intern (VA Volunteer)
  • BS, University of Wisconsin-Madison
Sareyah Ahmed
Undergraduate Researcher, Biology
Colin Boyle
Undergraduate Researcher, Biology
Megan Finke
Undergraduate Researcher, Biology
Gabriella Geiger
Undergraduate Researcher, Genetics
Elizabeth Konon
Undergraduate Researcher, Biology
Amy Lin
Undergraduate Researcher, Pharmacology and Toxicology
Emma Meyer
Undergraduate Researcher, Pharmacology and Toxicology
Blake Miller
Undergraduate Researcher
Alexis Mitchell
Undergraduate Researcher, Neurobiology and Psychology
Mark Morrison
Undergraduate Researcher
Jessica Norrlinger
Undergraduate Researcher
Shany Yang
Undergraduate Researcher, Neurobiology
Lab Alumni:
Emma Baar, Graduate Student, Northwestern University
  • BS, University of Wisconsin-Madison
Macy Barnes
Undergraduate Researcher, Nutritional Sciences and International Studies
Kathryn Carbajal, Research Intern, UW-Madison
  • BS, University of Wisconsin-Madison
Sara Cottrell, Undergraduate student, UW-Platteville
Elizabeth Williams, Medical Student, UW-Madison
  • BS, St. Olaf College
  • Shapiro Summer Research Program, UW-Madison
Monica (Julie) Kapp, Undergraduate Student, UW-Madison
Cassidy Pumper
Undergraduate Student, UW-Madison
Dawn Sherman, Medical Student, UW-Madison
  • BS, University of Wisconsin-Madison
Alice Shin, Graduate Student, University of Minnesota School of Pharmacy
  • BS, Massachusetts Institute of Technology
Faizan Syed, Manufacturing Lead, BioTechnique LLC, Madison WI
  • MS, BE Ramaiah Institute of Technology, Bangalore, India
  • Masters in Biotechnology Student, UW-Madison
Jessica Wu
Undergraduate Student, UW-Madison
Caroline Alexander, UW-Madison Alexander Lab
Alan Attie, UW-Madison Attie Lab
Joseph Baur, University of Pennsylvania Baur Lab
Vincent Cryns, UW-Madison Cryns Lab
Dawn Davis, UW-Madison Davis Lab
Luigi Fontana, Washington University in St. Louis
Philip Gruppuso, Brown University Gruppuso Lab
Michelle Kimple, UW-Madison Kimple Lab
Matthew Merrins, UW-Madison Merrins Lab
David Pagliarini, UW-Madison Pagliarini Lab

last modified: 5/19/17 Contact: