Publications

A complete list of Dr. Lamming's Publications can be found on Pubmed

The Biology of Aging and mTOR

Recent publications:

• Hypothalamic mTORC2 is essential for metabolic health and longevity, Aging Cell, 2019
• Age-Dependent Protection of Insulin Secretion in Diet Induced Obese Mice, Scientific Reports, 2018
• Pancreatic Beta cells from Mice Offset Age-Associated Mitochondrial Deficiency with Reduced KATP Channel Activity, Diabetes, 2016
• Sex- and tissue-specific changes in mTOR signaling with age in C57BL/6J mice, Aging Cell, 2015

Recent reviews:

• mTOR: The Grand ConducTOR of Metabolism and Aging, Cell Metabolism, 2016
• Diminished mTOR signaling: a common mode of action for endocrine longevity factors, Springerplus, 2014

Recent protocols:

• A toolbox for the longitudinal assessment of healthspan in aging mice, Nature Protocols, 2020

Dietary Interventions in Age-Related Disease

Recent publications:

• Calorie Restriction-Induced Insulin Sensitivity Is Mediated by Adipose mTORC2 and Not Required for Lifespan Extension, Cell Reports, 2019
• The Metabolic Response to a Low Amino Acid Diet is Independent of Diet-Induced Shifts in the Composition of the Gut Microbiome, Scientific Reports, 2019
• Short-term methionine deprivation improves metabolic health via sexually dimorphic, mTORC1-independent mechanisms, FASEB J, 2018
• Restoration of metabolic health by decreased consumption of branched-chain amino acids, Journal of Physiology, 2018
• Decreased Consumption of Branched-Chain Amino Acids Improves Metabolic Health, Cell Reports, 2016

Recent reviews:

• Regulation of metabolic health by essential dietary amino acids, Mechanisms of Ageing and Development, 2018
• Regulation of metabolic health and aging by nutrient-sensitive signaling pathways, Molecular and Cellular Endocrinology, 2016

Rapamycin and rapalogs

Recent publications:

• A novel rapamycin analog is highly selective for mTORC1 in vivo, Nature Communications, 2019
• Rapamycin blocks induction of the thermogenic program in white adipose tissue, Diabetes, 2016
• Intermittent administration of rapamycin extends the lifespan of female C57BL/6J mice, JGBS, 2016
• Alternative rapamycin treatment regimens mitigate the impact of rapamycin on glucose homeostasis and the immune system, Aging Cell, 2015

Recent reviews:

• Next generation strategies for geroprotection via mTORC1 inhibition, JGBS, 2019
• Rapamycin: An InhibiTOR of Aging Emerges From the Soil of Easter Island, JGBS, 2016

Older selected publications:

• Restriction of dietary protein decreases mTORC1 in tumors and somatic tissues of a tumor-bearing mouse xenograft model, Oncotarget, 2015
• Metabolic Effects of Caloric Restriction, eLS, 2014
• Depletion of Rictor, an essential protein component of mTORC2, decreases male lifespan, Aging Cell, 2014
• Lamming DW, Demirkan G, Boylan JM, Mihaylova MM, Peng T, Ferreira J, Neretti N, Salomon A, Sabatini DM, Gruppuso PA. Hepatic signaling by the mechanistic target of rapamycin complex 2 (mTORC2). FASEB J. 2014; 28(1):300-15. doi: 10.1096/fj.13-237743.(PubMed Link) (PDF)
• Lamming DW, Ye L, Astle CM, Baur JA, Sabatini DM, Harrison DE. Young and old genetically heterogeneous HET3 mice on a rapamycin diet are glucose intolerant but insulin sensitive. Aging Cell. 2013; 12(4):712-8. doi: 10.1111/acel.12097.(PubMed Link) (PDF)
• Lamming DW, Ye L, Katajisto P, Goncalves MD, Saitoh M, Stevens DM, Davis JG, Salmon AB, Richardson A, Ahima RS, Guertin DA, Sabatini DM, Baur JA. Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity. Science. 2012; 335(6076):1638-43. Epub 2012/03/31. doi: 10.1126/science.1215135.(PubMed Link) (PDF)